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Research & Grants

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Department of Pediatrics – General

Along with seven peer institutions, Children's Hospital Colorado has been awarded an 18-month contract for the proposal "A National Pediatric Learning Health System" in response to the PCORI announcement Improving Infrastructure for Conducting Patient-Centered Outcomes Research: Phase One – Clinical Data Research Networks. This collaborative national network will operationalize the concept of the learning healthcare system. Leading pediatric centers across the country will collaborate to share data from electronic health records, engage patient/family advisors to inform the research agenda, and will build capacity to perform patient-centered outcomes research in three topical areas: inflammatory bowel disease, congenital heart disease, and obesity. Total budget $7,000,000/18months, $450,000 total costs to each institution.

  • Colorado Site Principal Investigator – Michael G. Kahn, MD, PhD; Professor, Section of Pediatric Epidemiology, CCTSI Biomedical Informatics, University of Colorado
  • Senior Systems Official – Frederick Suchy, MD; Chief Research Officer, Children's Hospital Colorado, Pediatrics, GI
  • Co-Investigator Healthy-Weight Lead – Matthew Haemer, MD, MPH; Pediatrics, Nutrition
  • Co-Investigator Informatics Lead – Eric Tham, MD; Pediatrics, Emergency Medicine
  • Inflammatory Bowel Disease Lead – Edward Hoffenberg, MD; Pediatrics, GI
  • Congenital Heart Disease Lead – Jonathan Kaufman, MD; Pediatrics, Critical Care

The Department of Pediatrics received a $48.4 million five-year grant from the National Institutes of Health, which will, in part; continue funding for Children's Colorado's Clinical and Translational Research Center.

Center for Global Health

The construction of a $1 million medical center in southwest Guatemala is marking the University of Colorado School of Medicine of Colorado (CU) School of Medicine's first long-term presence in a developing nation. Edwin Asturias, MD, Assistant Professor of Pediatrics and Director for Latin America at the Center for Global Health, last July led team of CU physicians and students to assess the health needs of the population, conducting physicals and testing children for parasites and anemia. When completed, CU health care professionals will rotate through the facility, which is to be built on 10 acres of a banana plantation, treating some 3,000 workers and caring for the 24,000 people living in the surrounding villages. The project is funded by a donation from the Jose Fernando Bolaños Foundation.

Child Neurology

The University of Colorado has been awarded The Bugher Grant to be referred to as the "University of Colorado Anschutz Medical Campus ASA/Bugher Foundation Stroke Collaborative Research Center" from the American Stoke Association – Bugher Foundation Center for Excellence. It was in due to the joint efforts of the Stroke Team including Drs. Bernard, Armstrong-Wells, and Boada that the University received this prestigious award. This is a multi-year grant comprising 4 components: 2 basic science projects, a clinical project and a stroke research fellowship.

Emergency Medicine

Lalit Bajaj, MD, MPH, is the principal investigator in the NIH/NIAA study, titled "Teen Alcohol Screening in the Pediatric Emergency Care Applied Research Network."

Gastroenterology, Hepatology and Nutrition

Glenn T. Furuta, MD, is the principle investigator of the "Patient Related Research in Eosinophilic Gastrointestinal Diseases" Study (NIH 1K24DK100303), and has received $880,000 in grant monies. Dr. Furuta is also the principle investigator of the " Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis" Study (FDA-R01FD004086), and has received $1,400,000 in grant monies.

General Academic Pediatrics

Allison Kempe, MD, MPH, was the recipient of a $2.4 million, 5-year grant from the U.S. Agency for Healthcare Research and Quality to implement and evaluate an evidence-based method of increasing immunization rates within an ACO-public health collaborative.

Genetics and Metabolism

Jan P. Kraus, PhD, has pioneered a treatment approach to develop an enzyme replacement therapy for Cystathionine Beta-Synthase (CBS) – deficient homocystinuria, a rare, inherited metabolic disease that is often fatal at a young age. The University of Colorado has signed exclusive, worldwide licensing and collaboration agreements with Orphan Technologies Ltd, (OT) to develop an enzyme replacement therapy for CBS. OT plans to begin first-in-human trials in 2014.

Johan L. Van Hove, MD, PhD, has identified a new disease related to non-ketotic hyperglycinaemia (NKH), a finding that resolves previously baffling cases. The research team led by Van Hove, included scientists from the U.S. and five other countries. Van Hove has been on the trail of NKH for 22 years. Much of the funding for his research comes from families and others who have encountered the disease.

Neonatology

William W. Hay, Jr., MD, is the principal investigator of the Discovery Program of the Bill & Melinda Gates Foundation "Grand Challenges Explorations Grant" (Number: OPP1061082), Novel Nutritional Strategies to Treat Intrauterine Growth Restriction (IUGR). The purpose of this research project is to determine fetal metabolic adaptations that occur in response to chronic under nutrition in utero in fetal sheep and produce IUGR.

Paul J. Rozance, MD, received a NIH Research Project Grant as the Principal Investigator for "Nutrient Coordination of Pancreatic Vasculature and Beta-Cells." He is also a co-investigator on the Bill & Melinda Gates Foundation Grand Challenges Explorations Grant "Novel Nutritional Strategies to Treat IUGR."

Pulmonology

Carl White, MD, and his lab received a new grant supplement titled, "Regulatory Guidance for Fibrinolytic Therapy for Sulfur Mustard Inhalation" for the purpose of getting FDA approval for fibrinolytic therapy for airway injury due to toxic chemical inhalation. This parent grant, NIH U54 Program Grant is titled, "Novel Therapeutics for Vesicants and Toxic Inhaled Chemicals."

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